Rabbi Daniel Lapin in his book, Thou Shall Prosper: Ten Commandments for Making Money talks about having a perspective of being in business for oneself.
Seeing yourself as self-employed rather than working for someone else is a huge attitude shift. Realizing that how you interact with others today is more important than the classes you took back in college is a major change in perspective.
The great thing is that no matter what you do, even if you are currently unemployed, you can change your outlook. You may not be able to change your aptitude right away, but you can change your attitude.